Scientific Paper Topics

Hypercholesterolemia
  • Comparing simvastatin & atorvastatin for the treatment of hypercholesterolemia
  • Rosuvastatin versus simvastatin for the treatment of hypercholesterolemia
  • Comparing simvastatin to ezetimibe for the treatment of hypercholesterolemia
  • Comparing ezetimibe/simvastatin combination therapy vs. simvastatin monotherapy for the treatment of hypercholesterolemia
  • Rosuvastatin versus atorvastatin for the treatment of hypercholesterolemia
  • Comparing ezetimibe/simvastatin combination therapy vs. atorvastatin monotherapy for the treatment of hypercholesterolemia
  • Fenofibrate versus atorvastatin for the treatment of hypercholesterolemia
  • Extended-release niacin vs ezetimibe for the treatment of hypercholesterolemia
  • Extended-release niacin/simvastatin vs simvastatin monotherapy for the treatment of hypercholesterolemia
  • Pitavastatin versus atorvastatin for the treatment of hypercholesterolemia
  • Comparing ezetimibe/ atorvastatin combination therapy vs. atorvastatin monotherapy for the treatment of hypercholesterolemia
  • Comparing alirocumab plus atorvastatin versus atorvastatin plus ezetimibe for lowering low-density lipoprotein cholesterol (LDL-C)
  • Comparing alirocumab plus atorvastatin versus a double dose of atorvastatin for lowering low-density lipoprotein cholesterol (LDL-C)
Hypertension
  • Comparing the treatment of hypertension with atenolol and aetoprolol
  • Comparing the treatment of hypertension with benazepril and amlodipine
  • Comparing candesartan to amlodipine for the treatment of hypertension
  • Amlodipine vs. losartan/hydrochloriazide for treating hypertension
  • Amlodipine vs. valsartan/hydrochloriazide for treating hypertension
  • Amlodipine vs. atenolol for treating hypertension
Heart disease & other cardiovascular topics
  • Telmisartan, ramipril, or both for treating patients at risk for vascular events
  • Comparing prasugrel versus clopidogrel to treat Acute Coronary Syndromes
  • Comparing clopidogrel and aspirin to aspirin for the prevention of future atherothrombotic events
  • Everolimus-eluting stents vs. paclitaxel-eluting stents for treating coronary artery disease
  • Comparing ticagrelor to clopidogrel for treating acute coronary syndromes
  • Comparing fondaparinux to enoxaparin in patients in the treatment of acute coronary syndromes
  • Valsartan vs. captopril for treatment after a myocardial infarction
  • Valsartan, vs. captopril & valsartan for treatment after a myocardial infarction
  • Captopril vs. captopril & valsartan for treatment after a myocardial infarction
  • Dabigatran vs. warfarin in the treatment of atrial fibrillation
  • Dabigatran vs. warfarin in the treatment of venous thromboembolism
  • Edoxaban vs. warfarin in the treatment of atrial fibrillation
  • Rivaroxaban vs. warfarin in the treatment of atrial fibrillation
  • Pantoprazole vs. esomeprazole on the anti-platelet effects of clopidogrel
  • Comparing amiodarone to sotalol for the treatment of atrial fibrillation
  • Comparing apixaban to warfarin for the treatment of atrial fibrillation
  • Comparing fondaparinux to enoxaparin for treating acute coronary syndromes
  • Nesiritide vs. nitroglycerin for treating heart failure
  • Clopidogrel & omeprazole vs. clopidogrel alone for treating coronary artery disease
  • Everolimus-eluting stents compared to sirolimus-eluting stents for treating coronary artery disease
  • Aspirin + warfarin versus aspirin alone for treating acute coronary syndromes
  • Everolimus-eluting stents compared to sirolimus-eluting stents in patients with diabetes
  • Everolimus-eluting stents compared to paclitaxel-eluting stents in patients with diabetes
  • Comparing aspirin to warfarin with Bleeding Complications in the treatment of acute coronary syndromes
  • Comparing vorapaxar versus vorapaxar with clopidogrel for treating patients after non-ST-segment elevation acute coronary syndromes
Diabetes
  • Comparing metformin and glyburide in a combination medication as well as monotherapy in the treatment of diabetes mellitus type II
  • Comparing exenatide versus insulin glargine in the treatment of diabetes mellitus type II
  • Comparing insulin glulisine vs. insulin lispro for treating type II diabetes
  • Rosiglitazone vs. pioglitazone for treating type II diabetes
  • Rosiglitazone vs. pioglitazone for diabetic patients at risk for coronary heart disease
  • Rosiglitazone vs. insulin for diabetic patients at risk for coronary heart disease
  • Pioglitazone vs. insulin for diabetic patients at risk for coronary heart disease
  • Liraglutide vs. glimepiride to treat type II diabetes
  • Metformin vs. Actos for treating diabetes
  • Comparing liraglutide to exenatide for treating type II diabetes
  • Diet and exercise versus pioglitazone for treating obesity
  • Insulin glulisine vs. insulin lispro for treating diabetes
  • Comparing metformin to sulfonylureas: cardiovascular and all-cause mortality
Osteoporosis
  • Alendronate vs. risedronate for treating osteoporosis
  • Teriparatide and denosumab versus teriparatide alone for treating osteoporosis
  • Teriparatide and denosumab versus denosumab alone for treating osteoporosis
  • Ibandronate versus risedronate for treating osteoporosis
Gall bladder disease
  • Comparing ursodeoxycholic acid alone to ursodeoxycholic acid with chenodeoxycholic acid for treating gallstones
Ulcers
  • Omeprazole versus lansoprazole in treating gastric ulcer complications
  • Comparing esompeprazole versus pantoprazole for treating gastric ulcers
  • Omeprazole versus ranitidine in the treating of gastric ulcers
  • Omeprazole versus rabeprazole for the treating peptic ulcers
Other related topics
  • Omeprazole versus rabeprazole for treating Gastro-Esophageal Reflux Disease
  • Famotidine vs. lansoprazole for treating gastrointestinal conditions
  • Pantoprazole vs. nizatidine for treating erosive oesophagitis
  • Comparing pantoprazole versus ranitidine for treating Gastro-Esophageal Reflux Disease
  • Esomeprazole vs. lansoprazole for treating Gastro-Esophageal Reflux Disease
Bacterial
  • Tigecycline versus levofloxacin for treating community-acquired pneumonia
  • Azithromycin versus amoxicillin/clavulanate for treating acute sinusitis
  • Azithromycin versus amoxicillin/clavulanate for treating otitis media
  • Comparing cefdinir to amoxicillin/clavulanate for treating of otitis media
  • Tigecycline versus vancomycin for treating methicillin-resistant Staphylococcus aureus infections
  • Daptomycin vs. linezolid for treating Staphylococci and/or Enterococci infections
  • Vancomycin vs. metronidazole for treating Clostridium difficile infections
  • Benzoyl peroxide vs. benzoyl peroxide/clindamycin for treating acne
  • Benzoyl peroxide and clindamycin vs. benzoyl peroxide/clindamycin for treating acne
  • Vancomycin vs. linezolid for treating nosocomial pneumonia
  • Vancomycin vs. linezolid for treating methicillin-resistant Staphylococcus aureus infections
  • Comparing ciprofloxacin to trimethoprim-sulfamethoxazole for treating acute urinary tract infections in women
  • Comparing acellular whooping cough vaccines to whole cell whooping cough vaccines for children
  • Amoxicillin versus penicillin V for treating pharyngitis
  • Comparing fidaxomicin to vancomycin for treating a Clostridium difficile infection
  • Once-weekly rifapentine with isoniazid for 3 months versus isoniazid for 9 months in the prevention of active tuberculosis
  • Comparing minocycline to lymecycline for treating acne
Viral
  • Comparing oseltamivir to zanamivir for the treatment of influenza
  • Tenofovir vs. abacavir-lamivudine as a antiviral therapy
Protozoan
  • Artemether and lumefantrine versus artesunate and amodiaquine for treating malaria
Vaccinations
  • Comparing an new educational program to current practice for educating the public about the importance of vaccinations
  • Comparing two different dosage forms for vaccine delivery (for example: intra-nasal versus the subcutaneous delivery of measles vaccine)
  • Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis antigens (Tdap) vaccine versus tetanus and diphtheria toxoids vaccine (Td) for efficacy (and/or safety) in patients
  • Comparing efficacy of the quadrivalent flu vaccine to the trivalent flu vaccine
  • Measles-Mumps-Rubella (MMR) vaccine given to children at 8 months versus 12 months.
  • Comparing two doses of combined measles-mumps-rubella-varicella vaccine versus one dose of monovalent varicella vaccine for protecting against varicella
Alzheimer's disease & other dementias
  • Comparing rivastigmine vs. galantamine for treating Alzheimerâs disease
  • Comparing rivastigmine to donepezil for treating Alzheimerâs disease
  • Comparing rivastigmine and donepezil for the treatment of dementia
  • Memantine vs. donepezil for treating Alzheimerâs disease
  • Comparing galantamine to donepezil for treating Alzheimerâs disease
  • Comparing gingko biloba vs. donepezil for treating Alzheimerâs disease
  • Natural versus pharmacological treatments of Alzheimer's disease
Back pain
  • Comparing Avinza to OxyContin therapy for treating lower back pain
  • Comparing acupuncture to local anesthetic injections in the treatment of back pain
Chronic pain
  • Transdermal fentanyl vs. morphine for treating chronic pain
  • Chronic pain issues in the elderly
  • Morphine sulfate extended-release capsules vs. oxycodone hydrochloride for treating chronic pain
Epilepsy
  • Carbamazepine versus phenobarbitone for treating epilepsy
  • Comparing lamotrigine to phenytoin for treating epilepsy
  • Comparing lamotrigine to carbamazepine for treating epilepsy
  • Comparing lamotrigine to valproate for treating epilepsy
General and local anesthetics
  • Ketamine and morphineversus in pre-hospital anesthetics post-trauma
  • A Comparison of the side effects of intravenous propofol versus inhalant isoflurane for the use of anesthesia
Migraines
  • Topiramate vs. amitriptyline for treating migraines
  • Metoprolol vs. propranolol for treating migraines
Multiple Sclerosis
  • Oral fingolimod vs. intramuscular interferon for treating Multiple Sclerosis
Stroke
  • Comparing dipyridamole to aspirin for preventing strokes
  • Comparing warfarin to aspirin for preventing strokes Comparing tenecteplase to alteplase for treating ischemic strokes
Breast cancer
  • Comparing trastuzumab to bevacizumab for the treatment of breast cancer
  • Zoledronate versus ibandronate for the treatment of breast cancer
  • Anastrozole versus tamoxifen for the treatment of breast cancer
  • Letrozole versus tamoxifen for treating breast cancer
  • Letrozole versus anastrozole for treating breast cancer
Accelerated approval for new cancer drugs
  • Vemurafenib (formerly PLX4032) for treating metastatic melanoma. Find one randomized control trial comparing this drug to another drug. For your second article, find an article testing PLX4032 on cancer cell lines. Choose a review article of your choice.
  • Crizotinib for treating non-small cell lung cancer. See H. McEwen about the choosing your articles.
Lung cancer
  • Comparing gefitinib versus docetaxel in treating non-small-cell lung cancer
  • Comparing vorinostat/paclitaxel to paclitaxel alone for treating non-small-cell lung cancer
  • Comparing vorinostat/carboplatin to carboplatin alone for treating non-small-cell lung cancer
Other oncology topics
  • Denosumab versus zoledronic acid for treating bone metastases in advanced cancer
  • Ipilimumab and sargramostim compared to ipilimumab for treating metastatic melanoma
Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder
  • Adderall vs. Ritalin for treating Attention-deficit Hyperactivity Disorder
Depression
  • Comparing St. Johnâs wort to fluoxetine for treating depression
  • Comparing venlafaxine to sertraline for treating depression
  • Tamoxifen vs. medroxyprogesterone for treating bipolar disorder
  • Comparing St. Johnâs wort to impramine for treating depression
  • Venlafexine vs. mirtazapine for treating depression
  • Duloxetine vs. venlafaxine for treating depression
  • Sertraline vs. citalopram for treating depression
  • Duloxetine versus escitalopram for The treatment of major depressive disorder
  • venlafaxine vs. sertraline for treating depression
Generalized anxiety disorders
  • Comparing tiagabine to vigabatrin in the treatment of anxiety disorders
  • Comparing duloxetine vs aripiprazole for treating generalized anxiety disorder
  • ComparIng escitalopram to paroxetine for the treatment of generalized anxiety disorder
  • ComparIng escitalopram to venlafaxine for the treatment of generalized anxiety disorder
Post-Traumatic Stress Disorder
  • Intensive treatment versus standard treatment for treating post-traumatic stress disorder
  • Comparing trauma-informed yoga to supportive women's health education for treating post-traumatic stress disorder
Schizophrenia
  • Comparing risperidone to olanzapine for the treatment of schizophrenia
  • Comparing olanzapine to clozapine for the treatment of schizophrenia
  • Aripiprazole versus haloperidol for treating schizophrenia
  • Haloperidol versus olanzapine for treating schizophrenia
  • Comparing lurasidone and ziprasidone for treating schizophrenia
Asthma
  • Comparing fluticasone with salmeterol versus fluticasone with montelukast to treat asthma
  • Comparing budesonide/formoterol (Symbicort) pressurized meter dose inhaler (pMDI) with budesonide/formoterol (Symbicort) dry powder inhalation (DPI) and budesonide (Pulmicort) pressurized meter dose inhaler (pMDI) for treating asthma
  • Comparing salmeterol/fluticasone propionate versus fluticasone propionate for treating asthma
  • Comparing salmeterol/fluticasone propionate versus montelukast for treating asthma
  • Montelukast versus fluticasone for treating asthma
  • Albuterol versus levalbuterol for treating asthma
  • Bronchial thermoplasty versus conventional treatment for treating severe asthma
  • Comparison between inhaled corticosteroids and Leukotriene Receptor Antagonists for treating asthma in children
  • Safety of Bronchial Thermoplasty vs Conventional Methods for treating asthma
Chronic Obstructive Pulmonary Disease
  • Comparing salmeterol/fluticasone to tiotropium bromide for treating COPD
  • Comparing indacaterol to tiotropium for treating chronic obstructive pulmonary disease (COPD)
  • Comparing conventional to short-term glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease (COPD)
Pneumonia
  • Comparing vancomycin to linezolid for treating nosocomial pneumonia
  • Beta-lactam alone versus beta-lactam with a macrolide for treating community-acquired pneumonia
Osteoarthritis
  • Lumiracoxib versus celecoxib for treating osteoarthritis
  • Celecoxib versus diclofenac for treating arthritis
  • Celecoxib versus omeprazole and diclofenac for treating arthritis
  • Glucosamine/chondroitin versus chondroitin for treating osteoarthritis
  • Glucosamine/chondroitin versus glucosamine for treating osteoarthritis
  • Glucosamine versus chondroitin for treating osteoarthritis
Gout & Hyperuricemia
  • Febuxostat vs allopurinol for treating gout & hyperuricemia
Rheumatoid arthritis
  • Comparing infliximab to adalimumab for treating rheumatoid arthritis
  • Comparing infliximab to etanercept for treating rheumatoid arthritis
  • Comparing methotrexate with rituximab for the treatment of rheumatoid arthritis
  • Celecoxib vs. diclofenac for treating arthritis
  • Tocilizumab vs. methotrexate for treating rheumatoid arthritis
  • Celecoxib vs. omeprazole and diclofenac for treating arthritis
  • Comparing etanercept with methotrexate to an etanercept monotherapy for treating rheumatoid arthritis
Osteoporosis
  • Alendronate vs. risedronate for treating osteoporosis
  • Teriparatide and denosumab versus teriparatide alone for treating osteoporosis
  • Teriparatide and denosumab versus denosumab alone for treating osteoporosis
  • Ibandronate versus risedronate  for treating osteoporosis
Other Bone Related Topics
  • Pamidronate versus zoledronic acid for treating osteogenesis imperfecta
Cardiology related topics
  • Drug-eluting stents vesus bare metal stents for treating angina
  • Drug-eluting stents versus bare metal stents for teating acute coronary syndromes
  • Stents versus primary balloon angioplasty for treating acute myocardial infarction
  • Leg compression versus bed rest for treating of deep venous thrombosis
  • Mediterranean diet versus another type of diet forthe prevention of cardiovascular disease
Gastrointestinal related topics
  • Sigmoidoscopy versus fecal occult blood tests for colorectal cancer screening
  • comparing laparoscopic to open appendectomy
  • Computed virtual chromoendoscopy versus conventional colonoscopy
  • Helicobacter pylori test-and-treat versus prompt endoscopy for treating dyspepsia
Geriatrics
  • Exercise via tai chi for reducing falls in older adults
  • The effect of cognitive impairment on the risk of falling
  • Morning versus evening injection of teriparatide for treating (or preventing) osteorporosis
  • Comparing isosorbide mononitrate to alendronate for treating post menopausal osteoporosis
Infectious Diseases
  • Helicobacter pylori test-and-treat versus prompt endoscopy for treating dyspepsia
  • Comparing rapid antigen-detection tests to throat cultures for diagnosing Streptococcus infections
Neurology & Psychiatry
  • Comparing bed rest to staying active (exercise) for treating low back pain
  • Comparing anterior cervical discectomy with fusion to cervical discectomy without interbody fusion
  • Discogenic back pain: comparing surgical vs. nonsurgical treatments
  • Comparing acupuncture and local anesthesia in the treatment of back pain
  • Acupuncture versus conventional care for chronic lower back pain
  • Yoga versus usual care for treating lower back pain
  • Treating treatment resistant depression with electroconvulsive therapy vs. isoflurane anesthesia
  • Sertraline pharmacotherapy vs. electrical current therapy for treating depression
OB/GYN
  • Comparing laparoscopic hysterectomy to abdominal (open) hysterectomy
  • Laparoscopy versus laparotomy in treating endometrial cancer
  • HPV screening versus pap smear for detecting cervical cancer
  • Yoga versus exercise for treating menopausal symptoms
Oncology
  • Comparing ultrasonography and mammography to mammography alone for breast cancer screening
  • Comparing radical prostatectomy to watchful waiting fore treating early prostate cancer
  • HPV screening versus pap test for cervical cancer screening
  • Computed virtual chromoendoscopy vs. conventional colonoscopy
  • Laparoscopy versus laparotomy in treating endometrial cancer
Orthopedics
  • Single-bundle versus double-bundle anterior cruciate ligament reconstruction
  • Comparing patellar tendon to hamstring tendon autografts for treating anterior cruciate ligament reconstruction
  • Comparing supervised exercise to usual care for treating patellofemoral pain syndrome
  • Surgery versus non-surgical intervention for treating carpal tunnel syndrome
  • Corticosteroid injections compared to physiotherapy for treating lateral epicondylitis
  • Acupuncture versus usual care for low back pain
  • Comparing treatment of a fracture with surgery or a more conservative treatment
  • Milch technique versus the Stimson technique for treating shoulder dislocations
  • Surgery versus non-surgical interventions for treating bone fractures
  • Comparing walking boots to functional braces for treating ankle ligament injuries
  • Comparing two different exercise therapies for treating patellofemoral pain syndrome
  • Knee arthroscopy plus exercise versus exercise for treating patellofemoral pain syndrome
Respiratory
  • Tai Chi as a supplementary treatment for COPD
Miscellaneous
  • Bariatric surgery versus conventional care to treat diabetes
  • Mechanical versus manual chest compressions for cardiac arrest
  • Dissection versus diathermy for tonsillectomy
  • Tai chi versus usual care for treating chronic obstructive pulmonary disease
  • Comparison of a mobile app versus use of another type of diet for weight loss
  • Comparing weight loss using a low-fat diet versus a low-carbohydrate diet
  • Chimeric antigen receptor-modified T cells to treat leukemia. Special topic: see H. McEwen for help with article selection
  • Cognitive behavioral therapy versus Tai Chi for treating insomnia
  • Use of a smart phone application plus usual care versus usual care alone to treat type 1 diabetes
  • Comparing a mobile phone application to a text-messaging assessment of patients with schizophrenia and other mental health disorders
  • Comparing telemedicine versus telephone counseling for smoking cessation
  • Comparing telemedicine vs. telephone interventions for treating obesity in rural settings
  • Comparing peanut consumption and peanut avoidance in infants in order to prevent peanut allergies